Anti-CD52 (CAMPATH-1) (Mouse) mAb
Monoclonal antibody targeting CAMPATH-1/CD52 for FCM, IPP.
| Target | CAMPATH-1/CD52 |
|---|---|
| Product Type | Antibody |
| Application | FCM, IP |
| Clonality | Monoclonal |
| Conjugate | Unlabeled |
| Isotype | IgG2a |
| Immunogen | mouse IL-2R alpha-transgenic mouse splenocytes |
| Host Species | Rat |
| Species Reactivity | Mouse |
| Formulation | 100 µg IgG in 100 µL volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained. |
| Research Area | Cancer, Immunology, Apoptosis, Cell surface antigens |
| Description/Background | CAMPATH-1, also known as CD52, is a heavily glycosylated, GPI-anchored protein expressed at high levels on almost all thymocytes, lymphocytes, monocytes, and macrophages. The function of CD52 is unknown. However, CD52 is an exceptionally good target for complement-mediated cell lysis and antibody-mediated cellular cytotoxicity. Humanized CAMPATH-1antibodies have been used therapeutically to effectively deplete lymphocytes in allogeneic bone marrow transplants, hematologic malignancies, and autoimmune diseases. Clinical trials suggest CAMPATH-1 antibodies are especially promising in the treatment of leukemia, non-Hodgkin lymphomas, and rheumatoid arthritis. The apparent size of CAMPATH-1 by SDS-PAGE is 25-29 kDa; however, the actual molecule is much smaller, ~8-9 kDa as confirmed by total structure analysis and mass spectrometry. |
| Storage Temperature | This antibody solution is stable for one year from the date of purchase when stored at -20°C |
| Protocols | FCM, IP |
| Clone Number | BTG-2G |
| Concentration | 1 mg/mL |
| Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |
