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Anti-CD52 (CAMPATH-1) (Mouse) mAb

D204-3
Antibody
100 µl

$303.19

DATA SHEET

Monoclonal antibody targeting CAMPATH-1/CD52 for FCM, IPP.

TargetCAMPATH-1/CD52
Product TypeAntibody
ApplicationFCM, IP
ClonalityMonoclonal
ConjugateUnlabeled
IsotypeIgG2a
Immunogenmouse IL-2R alpha-transgenic mouse splenocytes
Host SpeciesRat
Species ReactivityMouse
Formulation100 µg IgG in 100 µL volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.
Research AreaCancer, Immunology, Apoptosis, Cell surface antigens
Description/BackgroundCAMPATH-1, also known as CD52, is a heavily glycosylated, GPI-anchored protein expressed at high levels on almost all thymocytes, lymphocytes, monocytes, and macrophages. The function of CD52 is unknown. However, CD52 is an exceptionally good target for complement-mediated cell lysis and antibody-mediated cellular cytotoxicity. Humanized CAMPATH-1antibodies have been used therapeutically to effectively deplete lymphocytes in allogeneic bone marrow transplants, hematologic malignancies, and autoimmune diseases. Clinical trials suggest CAMPATH-1 antibodies are especially promising in the treatment of leukemia, non-Hodgkin lymphomas, and rheumatoid arthritis. The apparent size of CAMPATH-1 by SDS-PAGE is 25-29 kDa; however, the actual molecule is much smaller, ~8-9 kDa as confirmed by total structure analysis and mass spectrometry.
Storage TemperatureThis antibody solution is stable for one year from the date of purchase when stored at -20°C
ProtocolsFCM, IP
Clone NumberBTG-2G
Concentration1 mg/mL
Regulatory StatementFor Research Use Only. Not for use in diagnostic procedures.
D204-3
Antibody
100 µl

$303.19

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