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MHC Tetramers

The ability to quantitate a T-cell response is an important piece of information for better understanding of various questions such as efficacy of new vaccines/therapies, evaluating disease progression or clearance, and many other questions.  T cell antigen receptors (TCR) recognize peptides that are expressed on antigen presenting cells.  Antigen specific T cell responses can be analyzed by using MHC tetramer molecules, where each monomer is bound with a specific peptide.  This method provides more robust T cell information compared to only using antibodies because the MHC tetramers will only bind to T cells that recognize the peptide sequence.  Using this method, it is certain that any signal that is observed is due to a specific T cell response and not due to an overall increase in T cell presence.

MHC tetramers are composed of four monomers, each with a specific peptide.  The monomers are biotinylated and held together using  fluorescently-labeled streptavidin.  Some researchers have found using MHC multimers with more than 4 monomers result in non-specific binding.  By using MHC tetramers, binding affinity of the peptide and TCR remains high, while reducing/avoiding low non-specific binding.

MBL International offers many alleles and sequence combinations for human and mouse MHC tetramers.  If you do not see your product of choice, please contact us for custom tetramer production.

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TB-5109-M2 {B} H-2 Db MCMV M45 Monomer-HGIRNASFIMCMV500 ugCall Read More
TB-5108-M2 {B} H-2 Db Survivin Monomer-ATFKNWPFLCancer500 ugCall Read More
TB-5111-M2 {B} H-2 Dd MCMV M164 Monomer-AGPPRYSRIMCMV500 ugCall Read More
TB-5110-M2 {B} H-2 Kb HBV HBsAg Monomer-VWLSVIWMHBV500 ugCall Read More
TB-5112-M2 {B} H-2 Ld MTB Ag85A Monomer-MPVGGQSSF500 ugCall Read More
TBCM5-DdC-M2 {B} H-2Dd Custom Monomer (CP)Custom500 ugCall Read More
TBCM5-DdC-M {B} H-2Dd Custom Monomer (CP)Custom50 µg$2,000.00
TBCM5-DdI-M2 {B} H-2Dd Custom Monomer (IP)Custom500 ugCall Read More
TB-0126-M2 {B} HLA-A*01:01 Tyrosinase Monomer-KSDICTDEY500 ugCall Read More
TB-0151-M2 {B} HLA-A*02:01 BA46 Monomer-GLQHWVPELCancer500 ugCall Read More
TB-0169-M2 {B} HLA-A*02:01 BCR-ABL Monomer-GVRGRVEEICancer500 ugCall Read More
TB-0158-M2 {B} HLA-A*02:01 CD20 Monomer-SLFLGILSVCancer500 ugCall Read More
TB-0131-M2 {B} HLA-A*02:01 EBV BALF4 Monomer-FLDKGTYTLEBV500 ugCall Read More
TB-0146-M2 {B} HLA-A*02:01 EBV LMP1 Monomer-YLLEMLWRLEBV500 ugCall Read More
TB-0164-M2 {B} HLA-A*02:01 EZH2 Monomer-YMCSFLFNLCancer500 ugCall Read More
TB-0134-M2 {B} HLA-A*02:01 GPC3 Monomer-FVGEFFTDVCancer500 ugCall Read More
TB-0122-M {B} HLA-A*02:01 HBV S protein Monomer-FLLTRILTI 50 ugHBV50 µg$1,400.00
TB-0122-M2 {B} HLA-A*02:01 HBV S protein Monomer-FLLTRILTI 500 ugHBV500 ugCall Read More
TB-0135-M2 {B} HLA-A*02:01 HIV Vif Monomer-GLADQLIHLHIV500 ugCall Read More
TB-0173-M2 {B} HLA-A*02:01 HPV16 E7 Monomer-MLDLQPETTHPV16500 ugCall Read More
TB-0128-M2 {B} HLA-A*02:01 hTERT Monomer-ALLTSRLRFICancer500 ugCall Read More
TB-0150-M2 {B} HLA-A*02:01 hTERT Monomer-GLLGASVLGLCancer500 ugCall Read More
TB-0133-M2 {B} HLA-A*02:01 HTLV bZIP Monomer-AVLDGLLSLHTLV500 ugCall Read More
TB-0170-M2 {B} HLA-A*02:01 IAPP Monomer-KLQVFLIVLDiabetes500 ugCall Read More

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