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MHC Tetramers

The ability to quantitate a T-cell response is an important piece of information for better understanding of various questions such as efficacy of new vaccines/therapies, evaluating disease progression or clearance, and many other questions.  T cell antigen receptors (TCR) recognize peptides that are expressed on antigen presenting cells.  Antigen specific T cell responses can be analyzed by using MHC tetramer molecules, where each monomer is bound with a specific peptide.  This method provides more robust T cell information compared to only using antibodies because the MHC tetramers will only bind to T cells that recognize the peptide sequence.  Using this method, it is certain that any signal that is observed is due to a specific T cell response and not due to an overall increase in T cell presence.

MHC tetramers are composed of four monomers, each with a specific peptide.  The monomers are biotinylated and held together using  fluorescently-labeled streptavidin.  Some researchers have found using MHC multimers with more than 4 monomers result in non-specific binding.  By using MHC tetramers, binding affinity of the peptide and TCR remains high, while reducing/avoiding low non-specific binding.

MBL International offers many alleles and sequence combinations for human and mouse MHC tetramers.  If you do not see your product of choice, please contact us for custom tetramer production.


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TS-HCD-1 T-Select Human CD1d Tetramer-SA-PENKT cells50 tests$1,400.00
TS-HCD-2 T-Select Human CD1d Tetramer - APCNKT cells50 tests$1,500.00
TS-MCD-1 T-Select Mouse CD1d Tetramer-SA-PENKT cells50 tests$1,400.00
TS-MCD-2 T-Select Mouse CD1d Tetramer - APCNKT cells50 tests$1,500.00
TSCM-3-A2301-1 Custom Tetramer/PE - HLA-A*23:01 (IP)Custom50 testsCall Read More
TSCM-3-A2301-2 Custom Tetramer/APC - HLA-A*23:01 (IP)Custom50 testsCall Read More
TSCM-3-A2301-3 Custom Tetramer/FITC - HLA-A*23:01 (IP)Custom50 testsCall Read More
TSCM-5-H2Dd Custom Biotinylated Tetramer - H-2Dd (IP)Custom50 µl$2,000.00
TS-0009-P HLA-A*02:01 Mart-1 peptideCancer/Melanoma100 μL (10 mg/mL)$210.00
TS-0010-P HLA-A*02:01 CMV pp65 peptideCMV100 μL (10 mg/mL)$210.00
TS-0012-P HLA-A*02:01 Influenza M1 peptideInfluenza100 μL (10 mg/mL)$210.00
TS-0018-P HLA-A*02:01 HBV core peptideHBV100 μL (10 mg/mL)$210.00
TS-0020-P HLA-A*24:02 CMV pp65 peptideCMV100 μL (10 mg/mL)$210.00
TS-0022-P HLA-A*24:02 HBV core peptideHBV100 μL (10 mg/mL)$210.00
TS-0029-P HLA-A*02:01 Negative peptideNegative100 μL (10 mg/mL)$210.00
TS-5001-P H-2Kb OVA peptideOVA100 μL (10 mg/mL)$210.00
TS-5004-P H-2Kb TRP-2 peptide (REPLACEMENT PRODUCT CODE: SP5004)NACall Read More
TS-5008-P H-2Db HPV16 E7 peptideHPV16100 μL (10 mg/mL)$210.00
TS-M001-P HLA-A*24:02 EBV LMP2 peptideEBV100 μL (10 mg/mL)$210.00
TS-M002-P HLA-A*24:02 EBV BRLF1 peptideEBV100 μL (10 mg/mL)$210.00
TS-M003-P HLA-A*24:02 EBV BMLF1 peptideEBV100 μL (10 mg/mL)$210.00
TS-M004-P HLA-A*24:02 EBV EBNA3A peptideEBV100 μL (10 mg/mL)$210.00
TS-M005-P HLA-A*24:02 EBV EBNA3B peptideEBV100 μL (10 mg/mL)$210.00
TS-M008-P H-2Kb SIY peptideModel100 μL (10 mg/mL)$210.00

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