Anti-CD52 (CAMPATH-1) (Mouse) mAb-PE (Monoclonal Antibody)
Monoclonal antibody conjugated to PE of 50 tests targeting CAMPATH-1/CD52 for FCM.
Target | CAMPATH-1/CD52 |
---|---|
Product Type | Antibody |
Application | FCM |
Clonality | Monoclonal |
Conjugate | PE |
Isotype | IgG2a |
Immunogen | Transgenic mouse spleen cell IL-2Ralpha |
Host Species | Rat |
Species Reactivity | Mouse |
Formulation | PBS/1% BSA/0.09% NaN3 |
Research Area | Immunology, Cell Biology |
Description/Background | CAMPATH-1, also known as CD52, is a heavily glycosylated, GPI-anchored protein expressed at high levels on almost all thymocytes, lymphocytes, monocytes, and macrophages. CAMPATH-1 is an exceptionally good target for complement-mediated cell lysis and antibody-mediated cellular cytotoxicity. Humanized CAMPATH-1 antibodies have been used therapeutically to effectively deplete lymphocytes in allogeneic bone marrow transplants, hematologic malignancies, and autoimmune diseases. Clinical trials suggest CAMPATH-1 antibodies are especially promising in the treatment of leukemia, non-Hodgkin lymphomas, and rheumatoid arthritis. The apparent size of CAMPATH-1 by SDS-PAGE is 25-29 kDa; however, the actual molecule is much smaller, ~ 8-9 kDa as confirmed by total structure analysis and mass spectrometry. |
Storage Temperature | 4°C |
Protocols | FCM |
Clone Number | BTG-2G |
Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |