Anti-Atg16L (Human) pAb (Polyclonal Antibody)
Polyclonal Antibody targeting Atg16L for ICC, IP, WB.
| Target | Atg16L |
|---|---|
| Product Type | Antibody |
| Application | ICC, IP, WB |
| Clonality | Polyclonal |
| Conjugate | Unlabeled |
| Isotype | Affinity Purified Ig |
| Immunogen | Recombinant human ATG16L1 TV2 (85-588 a.a.) |
| Host Species | Rabbit |
| Species Reactivity | Human, Hamster, Mouse, Rat |
| Formulation | PBS containing 50% glycerol, pH 7.2. No preservative is contained. |
| Research Area | Cancer, Immunology, Autophagy |
| Description/Background | Autophagy is a process of intracellular bulk degradation in which cytoplasmic components including organelles are sequestered within double-membrane vesicles that deliver the contents to the lysosome/vacuole for degradation. Autophagy has two ubiquitin-like conjugation systems, the Atg12 and LC3-II systems. In the Atg12 conjugation system, the Atg16L-Atg12-Atg5 forms 800 kDa complex that elongate autophagic isolation membrane. After completion of the formation of the autophagosome, the Atg12-Atg5-Atg16L complex dissociates from the membrane. In recent study, nonsynonymous SNP analysis has indicated that ATG16L1 is a Crohn’s disease susceptibility gene. |
| Storage Temperature | -20°C |
| Protocols | ICC, IP, WB |
| Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |
