Anti-Mouse CD8a Purified
The 2.43 monoclonal antibody specifically reacts with mouse CD8 antigen. CD8a (the alpha chains) form heterodimers with CD8b (the beta chains) or homodimers (alpha-alpha), which occur as receptors on the surface of the majority of thymocytes. A subpopulation of mature T lymphocytes expresses the CD8 alpha beta (alpha beta TCR T cells), and a subpopulation of intestinal intraepithelial lymphocytes and dendritic cells express CD8a without CD8b.
CD8 interacts with the mouse major histocompatibility complex class I (MHC class I) molecules on antigen-presenting cells or epithelial cells.
Application Notes The antibody has been analyzed for quality through the flow cytometric analysis of the relevant cell type. It is recommended that the reagent be titrated for optimal performance for each application.
| Target | CD8a |
|---|---|
| Product Type | Antibody |
| Application | FCM, FA, IHC |
| Clonality | Monoclonal |
| Conjugate | Purified |
| Isotype | IgG2b |
| Host Species | Rat |
| Species Reactivity | Mouse |
| Formulation | Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2. |
| Research Area | Adaptive Immunity, Flow Cytometry |
| Storage Temperature | The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product. |
| Protocols | FCM, FA, IHC |
| Clone Number | 2.43 |
| Concentration | 0.5 mg/mL |
| Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |
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