Target | IL-6 |
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Application | ELISA, FA, FC |
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Clonality | Monoclonal |
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Conjugate | Horseradish Peroxidase (HRPO) |
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Isotype | Human IgG1κ |
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Species Reactivity | Human |
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Formulation | This HRP-conjugated antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4, 1% BSA. (Warning: Use of sodium azide as a preservative will inhibit the enzyme activity of horseradish peroxidase) |
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Research Area | Cancer, Immunology |
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Description/Background | IL-6 and its signaling pathway play a part in immune response regulation, inflammation, and hematopoiesis.2 Sarilumab is a research-grade recombinant human monoclonal IL-6 receptor antagonist. It specifically binds to both the transmembrane and soluble forms of the IL-6 receptor, thus inhibiting IL-6–mediated cis and trans-signaling in a dose-dependent manner.1 Therapeutic Sarilumab, also known by the trade name Kevzara, is currently used to treat Rheumatoid Arthritis1, however, as of March 2020, The Feinstein Institute of Northwell Health publicized a study on "a human antibody that may prevent the activity" of IL-6 for the treatment of COVID-19.3 Anti-Human IL-6 (Sarilumab) utilizes the same variable regions from the therapeutic antibody Sarilumab making it ideal for research projects. |
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Storage Temperature | This horseradish peroxidase conjugated monoclonal antibody is stable when stored at 2-8°C. Do not freeze. |
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Protocols | ELISA, FA, FC |
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Clone Number | Hu137 |
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Concentration | 0.5 mg/ml |
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Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |
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