| Target | IL-12/IL-23 p40 |
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| Application | ELISA, FA, FC |
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| Clonality | Monoclonal |
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| Conjugate | Horseradish Peroxidase (HRPO) |
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| Isotype | Human IgG1λ |
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| Immunogen | This antibody was produced by phage display technology. |
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| Species Reactivity | Human |
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| Formulation | This HRP-conjugated antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4, 1% BSA. (Warning: Use of sodium azide as a preservative will inhibit the enzyme activity of horseradish peroxidase) |
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| Research Area | Cancer, Immunology |
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| Description/Background | Briakinumab is a human monoclonal antibody targets the p40 subunit shared by interleukins 12 and 23. IL-12 associates with IL-23α to form the heterodimeric cytokine IL-23. IL-23 is associated with various autoimmune inflammatory diseases, and is particularly highly expressed in psoriasis skin lesions. In addition, IL-23 is suspected to play a role in tumorigenesis. Briakinumab binds to and neutralizes human IL-12 and IL-23 (via their shared p40 subunit) and is being investigated for the treatment of rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis. Anti-Human IL 12/23 (Briakinumab) utilizes the same variable regions from the therapeutic antibody Briakinumab making it ideal for research projects. |
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| Storage Temperature | This horseradish peroxidase conjugated monoclonal antibody is stable when stored at 2-8°C. Do not freeze. |
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| Protocols | ELISA, FA, FC |
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| Clone Number | ABT-874 |
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| Concentration | 0.5 mg/ml |
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| Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |
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