| Target | VEGF |
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| Application | ELISA, FC |
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| Clonality | Monoclonal |
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| Conjugate | Horseradish Peroxidase (HRPO) |
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| Isotype | Human IgG1κ |
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| Immunogen | Recombinant human VEGF. |
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| Species Reactivity | Human |
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| Formulation | This HRP-conjugated antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4, 1% BSA. (Warning: Use of sodium azide as a preservative will inhibit the enzyme activity of horseradish peroxidase) |
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| Research Area | Cancer, Immunology |
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| Description/Background | Bevacizumab is a monoclonal antibody that specifically recognizes vascular endothelial growth factor (VEGF). VEGF is a growth factor that participates in angiogenesis, vasculogenesis, and endothelial cell growth. It facilitates endothelial cell proliferation, cell migration, and the permeabilization of blood vessels. In addition, VEGF inhibits apoptosis. Bevacizumab neutralizes the biological activity of VEGF by preventing the interaction of VEGF with its receptors on the surface of endothelial cells, resulting in the regression of tumor vascularization, normalization of remaining tumor vasculature, and inhibition of the formation of new tumor vasculature, thus inhibiting tumor growth.1 Anti-Human VEGF (Bevacizumab) utilizes the same variable regions from the therapeutic antibody Bevacizumab making it ideal for research projects. |
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| Storage Temperature | Functional grade biosimilar antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles. |
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| Protocols | ELISA, FC |
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| Clone Number | A4.6.1 |
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| Concentration | 0.5 mg/ml |
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| Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |
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