| Target | CD25 |
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| Application | FC, IF, IHC |
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| Clonality | Monoclonal |
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| Conjugate | R-phycoerythrin (PE) |
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| Isotype | Human IgG1κ |
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| Immunogen | Human CD25 |
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| Species Reactivity | Human, Cynomolgus Monkey, Rhesus Monkey |
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| Formulation | This R-phycoerythrin (R-PE) conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. |
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| Research Area | Cancer, Immunology |
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| Description/Background | CD25, a 55 kD type I transmembrane glycoprotein, has been shown to play roles in lymphocyte differentiation, activation, and proliferation. Many resting memory T cells constitutively express IL2Rα. It functions as the receptor for HTLV-1, resulting in its expression on neoplastic cells in adult T cell lymphoma/leukemia. CD25 (sIL-2R) has been used to track disease progression. Some additional clinical applications include Chagas disease, a disease characterized by a decline of CD25 expression on immune cells, and Multiple sclerosis, in which treatments with mAbs target CD25. Anti-Human IL-2R alpha (CD25) (Basiliximab) utilizes the same variable regions from the therapeutic antibody Basiliximab making it ideal for research projects. |
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| Storage Temperature | This R-phycoerythrin (R-PE) conjugate is stable when stored at 2-8°C. Do not freeze. |
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| Protocols | FC, IF, IHC |
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| Clone Number | Hu107 |
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| Concentration | 0.2 mg/ml |
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| Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |
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