| Target | CD194 |
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| Application | Depletion, ELISA, FA, FC |
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| Clonality | Monoclonal |
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| Conjugate | Biotin |
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| Isotype | Human IgG1κ |
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| Immunogen | Humanization of mouse anti-CCR4 mAb7. |
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| Species Reactivity | Human |
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| Formulation | This Biotinylated antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. |
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| Research Area | Cancer, Immunology |
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| Description/Background | Clone KW-0761 (Mogamulizumab) is a research-grade, afucosylated, humanized monoclonal antibody generated from mouse anti-CCR4 mAb7 that targets human CCR4.1 CC chemokine receptor type 4 (CCR4) is a protein that belongs to the G protein-coupled receptor family and is a receptor for a variety of CC chemokines including MCP-1, MIP-1, RANTES, TARC, and Macrophage-derived chemokine. Chemokines are involved in the development, homeostasis, and function of the immune system and are known to regulate cell trafficking of various types of leukocytes. In a 2018 Phase I clinical trial, Mogamulizumab was found to decrease the number of HTLV-1–infected cells and the levels of inflammatory markers related to HTLV-1–Associated Myelopathy.3 |
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| Storage Temperature | Functional grade biosimilar antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles. |
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| Protocols | Depletion, ELISA, FA, FC |
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| Clone Number | KW-0761 |
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| Concentration | 0.5 mg/ml |
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| Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |
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