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Anti-PCBP2 (Human) pAb (Polyclonal Antibody)

200 μL



Polyclonal Antibody of 200 µl targeting PCBP2 for IP, RIP, WB.

Product TypeAntibody
ApplicationIP, RIP, WB
IsotypeAffinity Purified Ig
ImmunogenInternal region synthetic peptide binding KLH, human PCBP2
Host SpeciesRabbit
Species ReactivityHuman, Mouse, Rat
Formulation200 μl volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.
Research AreaEpigenetics
Description/BackgroundPoly(rC)-binding proteins (PCBPs) are cellular RNA-binding proteins, characterized by their triple KH structure and by their poly(C)-binding specificity. The 3 KH domains are not only involved in nucleic acid binding but also mediate protein-protein interactions within the RNP complexes. It binds specifically to polypyrimidine tracts within the 3' UTR of target mRNAs through KH domains. PCBPs are expressed as 4 isoforms in cells. PCBP1 and PCBP2 are predominantly expressed in the nucleus and can shuttle from the nucleus to the cytoplasm, while PCBP3 and PCBP4 are expressed to a less extent in the cytoplasm. The most characterized gene regulated by PCBP1 and PCBP2 is the a-globin gene, and the accumulated α-globin mRNA is known to account for approximately 95% of total cellular mRNA during terminal erythroid differentiation. Specific binding of PCBPs to 3′ UTR of mRNA is associated with the stabilization of a-globin mRNA. Microarray analysis of human mRNAs present in a specific subset of PCBP2-RNP complexes also showed a potential involvement of PCBP2 in transcription factor expression via association with their mRNA; further, the enrichment of PCBP2 mRNA in PCBP2-RNP complexes suggested that PCBP2 expression may be subject to posttranscriptional autoregulation.
Storage Temperature-20°C
ProtocolsIP, RIP, WB
Concentration1 mg/mL
Regulatory StatementFor Research Use Only. Not for use in diagnostic procedures.
200 μL


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