Anti-ATBF1 (AT-6) (Human) pAb (Polyclonal Antibody)
Polyclonal Antibody of 100 µl targeting ATBF1 for IP, WB.
| Target | ATBF1 |
|---|---|
| Product Type | Antibody |
| Application | IP, WB |
| Clonality | Polyclonal |
| Conjugate | Unlabeled |
| Isotype | Affinity Purified Ig |
| Immunogen | C-terminal region of mouse ATBF1 (3405-3549 aa) |
| Host Species | Rabbit |
| Species Reactivity | Human, Mouse, Rat |
| Formulation | 100 μl volume of PBS containing 50% glycerol, pH 7.2. Contains no preservative. |
| Research Area | Cancer, Immunology |
| Description/Background | ATBF1 (also known as ZFHX3) is a transcription factor that has two-protein isoforms, the 404 kDa ATBF1-A and the 306 kDa ATBF1-B. ATBF1-A contains four homeodomains and 23 zinc-finger motifs. ATBF1-B contains four homeodomains and 18 zinc fingers. ATBF1 is identified as DNA-binding protein, which binds to an AT-rich element of the human -fetoprotein (AFP) gene, as a result suppressing its transcription activity. ATBF1 is also involved in cell cycle arrest and cooperating with p53 to activate the p21Waf1/Cip1 promoter. ATBF1 is expressed in the differentiation fields in association with β-tubulin III and MAP2 that are the neuronal differentiation marker. ATBF1 plays a crucial role in neuronal development and cell cycle arrest. |
| Storage Temperature | -20°C |
| Protocols | IP, WB |
| Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |
