Anti-Fas (CD95) (Human) mAb (Monoclonal Antibody)
Monoclonal Antibody targeting Fas for FCM, NT, WB.
| Target | Fas |
|---|---|
| Product Type | Antibody |
| Application | FCM, WB |
| Clonality | Monoclonal |
| Conjugate | Unlabeled |
| Isotype | IgG1 |
| Immunogen | Recombinant human Fas |
| Host Species | Mouse |
| Species Reactivity | Human |
| Formulation | 100 g IgG in 100 L volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained. |
| Research Area | Apoptosis |
| Description/Background | It is now widely accepted that apoptosis plays an important role in the selection of immature thymocytes and Ag-primed peripheral T cells. Fas (also known as CD95/APO-1) is a cell surface protein belonging to the tumor necrosis factor receptor superfamily, which is expressed in a variety of normal and neoplastic cells. Binding of FasL to Fas or crosslinking of Fas by anti-Fas monoclonal antibodies results in rapid induction of apoptosis in Fas expressing cells. Clone ZB4 is known as Fas blocking, Fas neutralizing or Fas antagonistic antibody, whereas anti-Fas antibody (clone CH-11) is known as the agonistic antibody. |
| Storage Temperature | -20°C |
| Protocols | FCM, WB |
| Clone Number | ZB4 |
| Concentration | 1 mg/mL |
| Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |
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