P2RY12 / P2Y12 Antibody (N-Terminus) (US Only)
P2RY12 / P2Y12 Rabbit anti-Human Polyclonal (N-Terminus) Antibody for IHC, IHC-P, ICC. For sale In the US only.
Important Note: During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. We recommend briefly centrifuging the vial to dislodge any liquid in the container’s cap prior to opening.
Warning: This reagent may contain sodium azide. The chemical, physical, and toxicological properties of this material have not been thoroughly investigated. Standard Laboratory Practices should be followed. Avoid skin and eye contact, inhalation, and ingestion. Sodium azide forms hydrazoic acid under acidic conditions and may react with lead or copper plumbing to form highly explosive metal azides. On disposal, flush with large volumes of water to prevent accumulation.
Important Note: During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. We recommend briefly centrifuging the vial to dislodge any liquid in the container’s cap prior to opening.
Warning: This reagent may contain sodium azide. The chemical, physical, and toxicological properties of this material have not been thoroughly investigated. Standard Laboratory Practices should be followed. Avoid skin and eye contact, inhalation, and ingestion. Sodium azide forms hydrazoic acid under acidic conditions and may react with lead or copper plumbing to form highly explosive metal azides. On disposal, flush with large volumes of water to prevent accumulation.
| Target | P2RY12, P2Y12 |
|---|---|
| Product Type | Antibody |
| Application | IHC, IHC - Paraffin (32 μg/ml), ICC |
| Clonality | Polyclonal |
| Conjugate | unconjugated |
| Immunogen | P2RY12 / P2Y12 antibody was raised against synthetic 17 amino acid peptide from N-Terminus extracellular domain of human P2RY12 / P2Y12. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Monkey (94%); Gibbon, Marmoset (88%); Pig (82%). |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Formulation | PBS, 0.1% Sodium Azide |
| Research Area | GPCR / Purinergic, Neuroscience |
| Description/Background | P2RY12 (P2Y12) is a G-protein coupled receptors, belonging to a family with different pharmacological selectivity for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation and is a target of antagonists for platelet inhibition in the treatment of coronary artery and cerebrovascular disease, thromboembolisms and other clotting disorders. In the brain, mediates microglia chemotaxis as part of closure of the blood-brain barrier following breakdown from injury. Mutations in this gene are implicated in bleeding disorder, platelet type 8 (BDPLT8). In immunohistochemistry, P2RY12 has membranous and cytoplasmic positivity in the amygdala, on small neurons of the caudate nucleus populations of nuclei in the medula, on astrocytes and in the posterior pituitary. In peripheral tissues, P2RY12 stains platelet pellets, bone marrow megakaryocytes, pancreatic islets, some lung pneumocytes, the bladder epithelium, gastrointestinal neuroendocrine cells, and Leydig cells of the testis. |
| Storage Temperature | Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles. |
| Protocols | IHC, IHC - Paraffin (32 μg/ml), ICC |
| Specificity | Human P2RY12 / P2Y12. BLAST analysis of the peptide immunogen showed no homology with other human proteins. N-Terminus |
| Concentration | 1 mg/ml |
| Purification | Immunoaffinity purified |
| Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |
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