CNR1 / CB1 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody (US Only)
CNR1 / CB1 Primary Antibody of 50 µg. For sale In the US only.
Important Note: During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. We recommend briefly centrifuging the vial to dislodge any liquid in the container’s cap prior to opening.
Warning: This reagent may contain sodium azide. The chemical, physical, and toxicological properties of this material have not been thoroughly investigated. Standard Laboratory Practices should be followed. Avoid skin and eye contact, inhalation, and ingestion. Sodium azide forms hydrazoic acid under acidic conditions and may react with lead or copper plumbing to form highly explosive metal azides. On disposal, flush with large volumes of water to prevent accumulation.
| Target | CNR1 / CB1 |
|---|---|
| Product Type | Antibody |
| Application | ICC, IHC, IHC-Paraffin |
| Clonality | Polyclonal |
| Conjugate | Unlabeled |
| Immunogen | Synthetic 18 amino acid peptide from 3rd cytoplasmic domain of human CNR1 / CB1. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Monkey, Mouse, Rat, Shrew, Hamster, Elephant, Cat (100%). |
| Host Species | Rabbit |
| Species Reactivity | Human, Hamster, Monkey, Mouse, Rat |
| Formulation | PBS, 0.1% Sodium Azide |
| Research Area | Cell Biology, Neuroscience |
| Description/Background | CNR1 (CB1, cannabinoid receptor type 1) is a G protein-coupled cannabinoid receptor that binds endocannabinoid neurotransmitters and their analogs in the brain. CNR1 functions include regulating cardiac blood supply, inhibiting neuronal excitability in the brain, regulating motor control, and reinforcing drug-seeking behavior in addiction. CNR1 is also an important modulator of anxiety and arousal in response to novel situations; loss of CNR1 has been found to lead to increased object exploration, social interaction and aggression in mice. In immunohistochemistry, CNR1 has membranous positivity in the peripheral and central nervous systems. It is also found on cells in the pituitary, thyroid and adrenal glands, on fat and muscle cells, and in the liver, retina, digestive tract, lungs and kidney. |
| Storage Temperature | Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles. |
| Protocols | ICC, IHC, IHC-Paraffin |
| Purification | Immunoaffinity purified |
| Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |
$504.00
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