Rhodopsin / RHO Antibody (Extracellular Domain) (US Only)
RHO Primary Antibody of 50 μg. For sale In the US only.
Important Note: During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. We recommend briefly centrifuging the vial to dislodge any liquid in the container’s cap prior to opening.
Warning: This reagent may contain sodium azide. The chemical, physical, and toxicological properties of this material have not been thoroughly investigated. Standard Laboratory Practices should be followed. Avoid skin and eye contact, inhalation, and ingestion. Sodium azide forms hydrazoic acid under acidic conditions and may react with lead or copper plumbing to form highly explosive metal azides. On disposal, flush with large volumes of water to prevent accumulation.
| Target | RHO |
|---|---|
| Product Type | Antibody |
| Application | IHC, IHC (P) |
| Clonality | Polyclonal |
| Conjugate | unconjugated |
| Immunogen | Synthetic 19 amino acid peptide from 2nd extracellular domain of human RHO / Rhodopsin. Percent identity with other species by BLAST analysis: Human, Monkey, Mouse, Rat, Rabbit, Pig, Cat, Elephant, Zebra finch (100%). (100%). |
| Host Species | Rabbit |
| Species Reactivity | Human, Monkey, Mouse, Pig, Rabbit, Rat |
| Formulation | PBS, 0.1% Sodium Azide |
| Research Area | Cell Biology, Neuroscience |
| Description/Background | Retinitis pigmentosa is an inherited progressive disease which is a major cause of blindness in western communities. It can be inherited as an autosomal dominant, autosomal recessive, or X-linked recessive disorder. In the autosomal dominant form,which comprises about 25% of total cases, approximately 30% of families have mutations in the gene encoding the rod photoreceptor-specific protein rhodopsin. This is the transmembrane protein which, when photoexcited, initiates the visual transduction cascade. Defects in this gene are also one of the causes of congenital stationary night blindness. |
| Storage Temperature | Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles. |
| Protocols | IHC, IHC (P) |
| Specificity | Human RHO / Rhodopsin. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Concentration | 1 mg/ml |
| Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |
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