| Target | MitoPLD |
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| Product Type | Antibody |
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| Application | IHC, IP, WB |
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| Clonality | Monoclonal |
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| Conjugate | Unlabeled |
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| Isotype | IgG2b ĸ |
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| Immunogen | KLH conjugated synthetic peptide, EFDPTKYSFFPQKHRGH (corresponding to amino acid residues 205-221 of mouse MitoPLD (Pld6) |
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| Host Species | Mouse |
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| Species Reactivity | Human, Mouse, Rat |
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| Formulation | PBS containing 50% Glycerol (pH 7.2). No preservative is contained |
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| Research Area | Epigenetics, Metabolism, RNA-RNP Network, Stem Cell Research |
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| Description/Background | MitoPLD (Pld6), the ortholog of drosophila Zucchini (Zuc), is a member of the phospholipase D superfamily. MitoPLD is strongly expressed in gonads especially in testis, and is located on the outer mitochondrial membrane. It is reported that MitoPLD hydrolyzes cardiolipin to generate phosphatidic acid (PA) at mitochondrial surface, and promotes mitochondrial fusion. PA, generated by MitoPLD, may work as a signaling molecule to regulate the localization and formation of mitochondria and intermitochondrial cement (nuage). It is also reported that the drosophila MitoPLD ortholog, Zuc, is an endoribonuclease essential for primary piRNA biogenesis by processing long non-coding RNA precursors. MitoPLD-/- mice show meiotic arrest during spermatogenesis, demethylation and derepression of retrotransposons, and defects in primary piRNA biogenesis, indicating that the role of MitoPLD/Zuc in the piRNA pathway is highly conserved among species. |
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| Storage Temperature | This antibody solution is stable for one year from the date of purchase when stored at -20°C. |
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| Protocols | IHC, IP, WB |
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| Clone Number | 26C46-6 |
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| Concentration | 1 mg/mL |
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| Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |
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