Anti-IL-33 (Mouse) mAb (Monoclonal Antibody) Functional Grade
Monoclonal Antibody targeting IL-33 for WB.
| Target | IL-33 |
|---|---|
| Product Type | Antibody |
| Clonality | Monoclonal |
| Conjugate | Unlabeled |
| Isotype | IgG1 ĸ |
| Immunogen | Mouse IL-33, 109-266 aa (recombinant) |
| Host Species | Mouse |
| Species Reactivity | Human, Mouse |
| Formulation | 1 mg/mL in PBS. Azide free, 0.22 μm sterile-filtered Endotoxin level is <0.5 EU/mg antibody, as determined by the LAL assay |
| Research Area | Immunology, Cytokine & Growth Factors |
| Description/Background | Interleukin-1 (IL-1) family, such as IL-1α/β and IL-18, has important functions in host defense, immune regulation, and inflammation. IL-33, a member of the IL-1 family, that shows to induce T helper (Th) type 2 responses by signaling through the IL-1 receptor-related protein ST2 (IL-1R4), an orphan member of the IL-1 receptor family. Similarly to IL-1α/β and IL-18, IL-33 is synthesized as a 31 kDa precursor protein has been shown to be cleaved by caspase-1 in vitro. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs. IL-33 has been originally identified as NF-HEV, which is a nuclear factor preferentially expressed in high endothelial venules. IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor involved in transcriptional regulation. |
| Storage Temperature | This antibody solution is stable for one year from the date of purchase when stored at 4°C. |
| Clone Number | 1F11 |
| Concentration | 1 mg/mL |
| Source | Purified IgG from hybridoma supernatant |
| Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |
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