Anti-CD8 (Mouse) mAb-Alexa Fluor® 647
Monoclonal antibody conjugated to Alexa Fluor® 647 for targeting CD8 for FCM.
| Target | CD8 |
|---|---|
| Product Type | Antibody |
| Application | FCM |
| Clonality | Monoclonal |
| Conjugate | Alexa Fluor® 647 |
| Isotype | IgG2a λ |
| Host Species | Rat |
| Species Reactivity | Mouse |
| Formulation | 50 ug IgG in 50 uL volume of PBS containing 1% BSA and 0.1% ProClin 150. |
| Research Area | Immunology, Cell Biology |
| Description/Background | <p>The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two α chains, or a heterodimer composed of one α and one β chain. Both α and β chains share significant homology to immunoglobulin variable light chains. CD8 α chains bind to class-I MHC molecules α3 domains. CD8 identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing.This monoclonal antibody KT15 reacts with a non-polymorphic epitope on the mouse CD8 α chain (mouse Ly2.1 and Ly2.2 cells).</p> |
| Storage Temperature | 4°C |
| Protocols | FCM |
| Clone Number | KT15 |
| Concentration | 1 mg/mL |
| Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |
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