Anti-Flavocytochrome b558 (Human) mAb-PE (Monoclonal Antibody)
Monoclonal antibody conjugated to PE of 50 tests targeting Flavocytochrome b558 for FCM.
| Target | Flavocytochrome b558 |
|---|---|
| Product Type | Antibody |
| Application | FCM |
| Clonality | Monoclonal |
| Conjugate | PE |
| Isotype | IgG1 |
| Immunogen | Rich fraction of human cytochrome b |
| Host Species | Mouse |
| Species Reactivity | Human |
| Formulation | 50 tests in 1 mL volume of PBS containing 1% BSA and 0.1% ProClin 150. |
| Research Area | Cell Biology |
| Description/Background | The NADPH oxidase is a multicomponent enzyme that transfers electrons from NADPH to O2 to generate superoxide (O2-), a key part of the phagocytic or neutrophilic respiratory burst response. Flavocytochrome b558 is the catalytic component of the phagocyte NADPH oxidase. It is a transmembrane heterodimer composed of a large glycoprotein, gp91phox (PHagocyte OXidase) and a smaller protein, p22phox. Upon cell stimulation, flavocytochrome b558 assembles with p67phox, p47phox, and the GTP-binding protein Rac and becomes activated to generate O2-. Mutations in gp91phox, p22phox, or other components of the NADPH oxidase can result in chronic granulomatous disease, which is associated with significant morbidity and mortality due to a predisposition to recurrent bacterial and fungal infections. |
| Storage Temperature | 4°C |
| Protocols | FCM |
| Clone Number | 7D5 |
| Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |
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