Anti-IL-18 (Clone 159-12B) (Human) mAb (Monoclonal Antibody)
Monoclonal antibody of 100 µl targeting IL-18 for IP.
| Target | IL-18 |
|---|---|
| Product Type | Antibody |
| Application | IP |
| Clonality | Monoclonal |
| Conjugate | Unlabeled |
| Isotype | IgG2a |
| Immunogen | Recombinant human IL-18 |
| Host Species | Rat |
| Species Reactivity | Human |
| Formulation | 100 µg IgG in 100 µl volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained. |
| Research Area | Immunology |
| Description/Background | Interleukin 18 (IL-18) is a 18 kDa cytokine which identified as a costimulatory factor for production of interferon-g (IFN-g) in response to toxic shock and shares functional similarities with IL-12. IL-18 is synthesized as a precursor 24 kDa molecule without a signal peptide and must be cleaved to produce an active molecule. IL-1 converting enzyme (ICE, Caspase-1) cleaves pro-IL-18 at aspartic acid in the P1 position, producing the mature, bioactive peptide that is readily released from the cells. It is reported that IL-18 is produced from Kupffer cells, activated macrophages, keratinocytes, intestinal epithelial cells, osteoblasts, adrenal cortex cells and murine diencephalon. IL-18 acts on T helper type-1 (Th1) T cells and in combination with IL-12 strongly induces them to produce IFN-γ. Pleiotropic effects of IL-18 has also been reported, such as, enhancement production of IFN-γ and GM-CSF in peripheral blood mononuclear cells, production of Th1 cytokines, IL-2, GM-CSF and IFN-g in T cells, enhancement of Fas ligand expression by Th1 cells. |
| Storage Temperature | -20°C |
| Protocols | IP |
| Clone Number | 159-12B |
| Concentration | 1 mg/mL |
| Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |
