CircuLex Human FAM3D ELISA Kit

FAM3D (Family with sequence similarity 3, member D, also called as oncoprotein induced protein 1 (OIT1) and protein EF-7 has been suggested to be new kind of cytokine, because it has a 4-helix bundle structure, which is thought to be unique to growth factors and cytokines. The FAM3 family which includes FAM3A, FAM3B, FAM3C, and FAM3D is originally cloned as a novel cytokine-like gene family. While FAM3B is found in the pancreas, FAM3D is expressed strongly in the placenta and testis and weakly in the small intestine, and FAM3A and FAM3D are ubiquitously expressed (1). FAM3D is secreted from gut in a nutrient status-dependent manner (2). The expression of FAM3D is reported to increase in serum of colon cancer patients (3). It is also reported that the FAM3D gene is linked to
narcolepsy (4). FAM3D may play a role in the regulation of lipid and energy metabolism in mice and humans (3). There is also evidence that FAM3D plays a chemo-attractive role through its receptors FPR1 and FPR2 (formyl peptide receptors), both of which are highly expressed on the cell surface of neutrophils or monocytes/macrophages (5).