CircuLex Human Fibulin-1 ELISA Kit Ver.2
This kit is used for the quantitative measurement of human Fibulin-1 in serum samples.
| Target | Fibulin-1 |
|---|---|
| Product Type | ELISA Kit |
| Application | ELISA |
| Species Reactivity | Human |
| Research Area | Immunology, Metabolism |
| Description/Background | Fibulin-1 is the first described member of a seven-gene family of extracellular matrix (ECM) proteins that have a common structural signature consisting of a series of repeated EGF-like domains followed by a fibulin-type module at its carboxyl terminus. Fibulin-1 is a secreted glycoprotein that is an intercellular component of a wide range of connective tissues. In blood vessel walls, fibulin-1 is a component of elastic lamina and ECM fibers that surround smooth muscle cells and underlie the endothelium. Although its actual function remains to be elucidated, fibulin-1 has been suggested to be involved in cell adhesion, migration, proliferation, and malignant transformation through binding to many ECM proteins, including laminin, fibrinogen, fibronectin, nidogen-1, endostatin, β-amyloid precursor protein and proteoglycans, aggrecan, versican, receptors and growth factors. In addition, fibulin-1 has been found to bind to the plasma protein fibrinogen and to incorporate into fibrin clots formed in vitro and in vivo. Targeted inactivation of fibulin-1 gene in mice caused dilation and ruptures in the endothelial lining of small blood vessels, indicating that fibulin-1 was important in the stabilization of blood vessel walls. Fibulin-1 is one of a few ECM proteins normally found in blood in high concentrations (16). It was reported that plasma fibulin-1 concentrations increased in T2DM patients with prevalent cardiovascular disease destined for vascular surgery as well as in asthmatics. |
| Storage Temperature | 4°C |
| Protocols | ELISA |
| Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |
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