Phospho-Beclin 1-Ser15 Rabbit pAb
| Target | BECN1 |
|---|---|
| Product Type | Antibody |
| Application | WB |
| Isotype | IgG |
| Immunogen | A synthetic phosphorylated peptide around S15 of human Beclin 1 (NP_003757.1). |
| Host Species | Rabbit |
| Species Reactivity | Human, Mouse, Rat |
| Formulation | PBS with 0.05% proclin300,50% glycerol |
| Research Area | Cancer, Immunology |
| Description/Background | The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. The encoded protein plays an important role in the innate immune response against multiple DNA and RNA viruses. |
| Protocols | WB |
| Molecular Weight | 52kDa |
| Purity | Affinity purification |
| Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |