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Phospho-PKR/EIF2AK2-T446 Rabbit pAb

This product is only available in the US
CNAP1251P
Antibody
100 µl

$450.00

DATA SHEET

TargetEIF2AK2
Product TypeAntibody
ApplicationWB
IsotypeIgG
ImmunogenA synthetic phosphorylated peptide around T446 of human PKR/EIF2AK2 (NP_002750.1).
Host SpeciesRabbit
Species ReactivityHuman, Mouse
FormulationPBS with 0.05% proclin300,50% glycerol
Research AreaCancer, Immunology
Description/Background

The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

ProtocolsWB
Molecular Weight62kDa
PurityAffinity purification
Regulatory StatementFor Research Use Only. Not for use in diagnostic procedures.
This product is only available in the US
CNAP1251P
Antibody
100 µl

$450.00

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