Phospho-RIPK1/RIP-S166 Rabbit pAb
| Target | RIPK1 |
|---|---|
| Product Type | Antibody |
| Application | WB |
| Isotype | IgG |
| Immunogen | A synthetic phosphorylated peptide around S166 of human RIPK1/RIP (NP_003795.2). |
| Host Species | Rabbit |
| Species Reactivity | Human, Mouse |
| Formulation | PBS with 0.01% thimerosal,50% glycerol |
| Research Area | Cancer, Immunology |
| Description/Background | The protein encoded by this gene is a DNA binding cytosolic protein that catalyzes the synthesis of cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) after sensing the presence of DNA in the cytoplasm. cGAMP binds another protein, Stimulator of interferon genes (STING), leading to the induction of interferons, and a host immune response. Reduced expression of this gene inhibits interferon induction in the presence of some viral infections. Alternative splicing results in multiple transcript variants. |
| Protocols | WB |
| Molecular Weight | 76kDa |
| Purity | Affinity purification |
| Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |