Phospho-β-Catenin-S33/S37 Rabbit mAb
Target | CTNNB1 |
---|---|
Product Type | Antibody |
Application | WB |
Clonality | Monoclonal |
Isotype | IgG |
Immunogen | A synthetic phosphorylated peptide around S33 of human beta CateninCTNB1 (P35222). |
Host Species | Rabbit |
Species Reactivity | Human |
Formulation | PBS with 0.02% sodium azide,0.05% BSA,50% glycerol |
Research Area | Cancer, Immunology, Epigenetics |
Description/Background | The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This kinase is a component of two distinct complexes, mTORC1, which controls protein synthesis, cell growth and proliferation, and mTORC2, which is a regulator of the actin cytoskeleton, and promotes cell survival and cell cycle progression. This Protein A Affinity purificationcts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Inhibitors of mTOR are used in organ transplants as immunosuppressants, and are being evaluated for their therapeutic potential in SARS-CoV-2 infections. Mutations in this gene are associated with Smith-Kingsmore syndrome and somatic focal cortical dysplasia type II. The ANGPTL7 gene is located in an intron of this gene. |
Protocols | WB |
Molecular Weight | 85kDa |
Concentration | 2 mg/mL |
Purity | Affinity purification |
Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |