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Phospho-GRIN2B-Y1474 Rabbit pAb

This product is only available in the US
CNAP0771T
Antibody
100 µl

$450.00

DATA SHEET

TargetGRIN2B
Product TypeAntibody
ApplicationWB
ClonalityPolyclonal
IsotypeIgG
ImmunogenA synthetic phosphorylated peptide around Y1474 of human GRIN2B (NP_000825.2).
Host SpeciesRabbit
Species ReactivityHuman, Mouse, Rat
FormulationPBS with 0.01% thimerosal,50% glycerol
Research AreaCancer, Immunology
Description/Background

Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene.

ProtocolsWB
Molecular Weight166kDa
PurityAffinity purification
Regulatory StatementFor Research Use Only. Not for use in diagnostic procedures.
This product is only available in the US
CNAP0771T
Antibody
100 µl

$450.00

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