Phospho-POLR2A CTD-S2 Rabbit pAb
| Target | POLR2A |
|---|---|
| Product Type | Antibody |
| Application | IP, WB |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | A phospho specific peptide corresponding to residues surrounding S2 of human POLR2A CTD repeat YSPTSPS. |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Formulation | PBS with 0.01% thimerosal,50% glycerol |
| Research Area | Cancer, Immunology |
| Description/Background | The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5′ end of messenger RNAs. The encoded Protein A Affinity purificationids in translation initiation by recruiting ribosomes to the 5′-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. |
| Protocols | IP, WB |
| Molecular Weight | 217kDa |
| Purity | Affinity purification |
| Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |