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FBLN5 Rabbit pAb

This product is only available in the US
CNA9961S
Antibody
100 µl

$450.00

DATA SHEET

TargetFBLN5
Product TypeAntibody
ApplicationICC, IF, WB
ClonalityPolyclonal
IsotypeIgG
ImmunogenRecombinant fusion protein containing a sequence corresponding to amino acids 199-448 of human FBLN5 (NP_006320.2).
Host SpeciesRabbit
Species ReactivityHuman, Mouse, Rat
FormulationPBS with 0.02% sodium azide,50% glycerol
Research AreaCancer, Immunology
Description/Background

The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3).

ProtocolsICC, IF, WB
Molecular Weight50kDa
PurityAffinity purification
Regulatory StatementFor Research Use Only. Not for use in diagnostic procedures.
This product is only available in the US
CNA9961S
Antibody
100 µl

$450.00

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