WRN Rabbit pAb
Target | WRN |
---|---|
Product Type | Antibody |
Application | WB |
Clonality | Polyclonal |
Isotype | IgG |
Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1223-1432 of human WRN (NP_000544.2). |
Host Species | Rabbit |
Species Reactivity | Human |
Formulation | PBS with 0.02% sodium azide,50% glycerol |
Research Area | Cancer, Immunology, Epigenetics |
Description/Background | This gene encodes a member of the RecQ subfamily of DNA helicase proteins. The encoded nuclear protein is important in the maintenance of genome stability and plays a role in DNA repair, replication, transcription and telomere maintenance. This protein contains a N-terminal 3′ to 5′ exonuclease domain, an ATP-dependent helicase domain and RQC (RecQ helicase conserved region) domain in its central region, and a C-terminal HRDC (helicase RNase D C-terminal) domain and nuclear localization signal. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by accelerated aging and an elevated risk for certain cancers. |
Protocols | WB |
Molecular Weight | 162kDa |
Purity | Affinity purification |
Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |