UCP2 Rabbit pAb

Name: UCP2 Rabbit pAb
SKU: CNA4178T
Price: 450.00 USD
Availability: InStock

Code CNA4178T

Product Type Antibody

Size 100 µl

THIS ITEM HAS BEEN DISCONTINUED

Target	UCP2
Product Type	Antibody
Application	WB
Clonality	Polyclonal
Isotype	IgG
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 112-211 of human UCP2 (NP_003346.2).
Host Species	Rabbit
Species Reactivity	Human, Mouse, Rat
Formulation	PBS with 0.01% thimerosal,50% glycerol
Research Area	Cancer, Immunology, Metabolism
Description/Background	<p>Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5′-UCP3-UCP2-3′.</p>
Protocols	WB
Molecular Weight	33kDa
Purity	Affinity purification
Regulatory Statement	For Research Use Only. Not for use in diagnostic procedures.