NF-kB p65/RelA Rabbit mAb
Target | RELA |
---|---|
Product Type | Antibody |
Application | ChIP, ICC, IF, IHC (P), IP, WB |
Clonality | Monoclonal |
Isotype | IgG |
Immunogen | A synthetic peptide corresponding to a sequence within amino acids 450-551 of human NF-?B p65 (Q04206). |
Host Species | Rabbit |
Species Reactivity | Human, Monkey, Mouse, Rat |
Formulation | PBS with 0.05% proclin300,0.05% BSA,50% glycerol |
Research Area | Cancer, Immunology, Metabolism |
Description/Background | NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. |
Protocols | ChIP, ICC, IF, IHC (P), IP, WB |
Molecular Weight | 60kDa |
Purity | Affinity purification |
Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |