| Target | LEPR |
|---|
| Product Type | Antibody |
|---|
| Application | IHC (P), WB |
|---|
| Clonality | Monoclonal |
|---|
| Isotype | IgG |
|---|
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 1000-1100 of human Leptin Receptor (P48357). |
|---|
| Host Species | Rabbit |
|---|
| Species Reactivity | Human, Mouse, Rat |
|---|
| Formulation | PBS with 0.02% sodium azide,0.05% BSA,50% glycerol |
|---|
| Research Area | Cancer, Immunology, Metabolism |
|---|
| Description/Background | <p>The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).</p> |
|---|
| Protocols | IHC (P), WB |
|---|
| Molecular Weight | 132kDa |
|---|
| Concentration | 0.5 mg/mL |
|---|
| Purity | Affinity purification |
|---|
| Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |
|---|
![[KO Validated] active + pro Caspase-3 Rabbit mAb](https://products.mblintl.com/wp-content/uploads/2023/12/NO-PRODUCT-IMAGE.jpg)