Thioredoxin reductase 1 (TXNRD1 ) Rabbit pAb
Target | TXNRD1 |
---|---|
Product Type | Antibody |
Application | ICC, IF, IHC (P), WB |
Clonality | Polyclonal |
Isotype | IgG |
Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 410-490 of human Thioredoxin reductase 1 (TXNRD1) (Q16881). |
Host Species | Rabbit |
Species Reactivity | Human, Mouse, Rat |
Formulation | PBS with 0.01% thimerosal,50% glycerol |
Research Area | Cancer, Immunology, Metabolism |
Description/Background | The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3′ UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing, primarily at the 5′ end, results in transcript variants encoding same or different isoforms, including a glutaredoxin-containing isoform that is predominantly expressed in testis. |
Protocols | ICC, IF, IHC (P), WB |
Molecular Weight | 71kDa |
Purity | Affinity purification |
Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |