Smad7 Rabbit pAb
Target | Smad7 |
---|---|
Product Type | Antibody |
Application | ICC, IF, IHC (P), WB |
Clonality | Polyclonal |
Isotype | IgG |
Immunogen | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Smad7 (NP_005895.1). |
Host Species | Rabbit |
Species Reactivity | Human, Mouse, Rat |
Formulation | PBS with 0.01% thimerosal,50% glycerol |
Research Area | Cancer, Immunology, Epigenetics |
Description/Background | The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded Protein A Affinity purificationnd TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. |
Protocols | ICC, IF, IHC (P), WB |
Molecular Weight | 46kDa |
Purity | Affinity purification |
Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |