TriMethyl-Histone H3-K27 Mouse mAb
| Target | H3-4 |
|---|---|
| Product Type | Antibody |
| Application | ChIP, CUT and Tag, ICC, IF, IHC (P), WB |
| Clonality | Monoclonal |
| Isotype | IgG1kappa |
| Immunogen | A synthetic methylated peptide corresponding to residues surrounding K27 of human histone H3 |
| Host Species | Mouse |
| Species Reactivity | Human, Mouse, Other (Wide Range), Rat |
| Formulation | PBS with 0.05% proclin300,50% glycerol |
| Research Area | Cancer, Immunology, Epigenetics |
| Description/Background | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3. |
| Protocols | ChIP, CUT and Tag, ICC, IF, IHC (P), WB |
| Molecular Weight | 16kDa |
| Purity | Affinity purification |
| Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |