[KO Validated] CDK9 Rabbit mAb
| Target | CDK9 |
|---|---|
| Product Type | Antibody |
| Application | ChIP, ChIP-seq, CUT and Tag, ICC, IF, IHC (P), IP, WB |
| Clonality | Monoclonal |
| Conjugate | unconjugated |
| Isotype | IgG |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 273-372 of human CDK9 (P50750). |
| Host Species | Rabbit |
| Species Reactivity | Human, Mouse, Rat |
| Formulation | PBS with 0.02% sodium azide,0.05% BSA,50% glycerol |
| Research Area | Cancer, Immunology, Epigenetics |
| Description/Background | The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this Protein A Affinity purificationnd cyclin T, which suggested a possible involvement of this protein in AIDS. |
| Protocols | ChIP, ChIP-seq, CUT and Tag, ICC, IF, IHC (P), IP, WB |
| Molecular Weight | 43kDa |
| Purity | Affinity purification |
| Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |