Active Caspase-3 Rabbit mAb
| Target | CASP3 |
|---|---|
| Product Type | Antibody |
| Application | WB |
| Clonality | Monoclonal |
| Conjugate | unconjugated |
| Isotype | IgG |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CASP3 (P42574). |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Formulation | PBS with 0.05% proclin300,0.05% BSA,50% glycerol |
| Research Area | Cancer, Immunology |
| Description/Background | The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer’s disease. |
| Protocols | WB |
| Molecular Weight | 32kDa |
| Concentration | 1 mg/mL |
| Purity | Affinity purification |
| Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |