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HLA-DRB4 Rabbit mAb

This product is only available in the US
CNA0439S
Antibody
100 µl

$450.00

DATA SHEET

TargetHLA-DRB4
Product TypeAntibody
ApplicationWB
Conjugateunconjugated
IsotypeIgG
ImmunogenA synthetic peptide corresponding to a sequence within amino acids 50-150 of human HLA-DRB4 (P13762).
Host SpeciesRabbit
Species ReactivityHuman
FormulationPBS with 0.02% sodium azide,0.05% BSA,50% glycerol
Research AreaCancer, Immunology
Description/Background

HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. There are multiple pseudogenes of this gene.

ProtocolsWB
Components30kDa
Molecular Weight30kDa
PurityAffinity purification
Regulatory StatementFor Research Use Only. Not for use in diagnostic procedures.
This product is only available in the US
CNA0439S
Antibody
100 µl

$450.00

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