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Bcl-XL Rabbit pAb

This product is only available in the US
CNA0209T
Antibody
100 µl

$450.00

DATA SHEET

TargetBCL2L1
Product TypeAntibody
ApplicationICC, IF, IHC (P), WB
Conjugateunconjugated
IsotypeIgG
ImmunogenRecombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human Bcl-XL (NP_612815.1).
Host SpeciesRabbit
Species ReactivityHuman, Rat
FormulationPBS with 0.01% thimerosal,50% glycerol
Research AreaCancer, Immunology, Metabolism
Description/Background

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator.

ProtocolsICC, IF, IHC (P), WB
Components26kDa
Molecular Weight26kDa
PurityAffinity purification
Regulatory StatementFor Research Use Only. Not for use in diagnostic procedures.
This product is only available in the US
CNA0209T
Antibody
100 µl

$450.00

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