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ATF6 Rabbit pAb

This product is only available in the US
CNA0202P
Antibody
100 µl

$450.00

DATA SHEET

TargetATF6
Product TypeAntibody
ApplicationICC, IF, IHC (P), WB
Conjugateunconjugated
IsotypeIgG
ImmunogenRecombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human ATF6 (NP_031374.2).
Host SpeciesRabbit
Species ReactivityHuman, Mouse, Rat
FormulationPBS with 0.05% proclin300,50% glycerol
Research AreaCancer, Immunology, Epigenetics
Description/Background

This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis.

ProtocolsICC, IF, IHC (P), WB
Components75kDa
Molecular Weight75kDa
PurityAffinity purification
Regulatory StatementFor Research Use Only. Not for use in diagnostic procedures.
This product is only available in the US
CNA0202P
Antibody
100 µl

$450.00

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