Rad50 Rabbit pAb
| Target | RAD50 |
|---|---|
| Product Type | Antibody |
| Application | IHC (P), WB |
| Clonality | Polyclonal |
| Conjugate | unconjugated |
| Isotype | IgG |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 300-400 of human Rad50 (Q92878). |
| Host Species | Rabbit |
| Species Reactivity | Human, Mouse |
| Formulation | PBS with 0.02% sodium azide,50% glycerol |
| Research Area | Cancer, Immunology, Epigenetics |
| Description/Background | The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder. |
| Protocols | IHC (P), WB |
| Molecular Weight | 154kDa |
| Purity | Affinity purification |
| Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |