| Target | SPHK1 |
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| Product Type | Antibody |
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| Application | WB |
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| Clonality | Polyclonal |
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| Conjugate | unconjugated |
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| Isotype | IgG |
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| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 50-384 of human SPHK1 (NP_001136074.1). |
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| Host Species | Rabbit |
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| Species Reactivity | Human, Mouse |
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| Formulation | PBS with 0.02% sodium azide,50% glycerol |
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| Research Area | Cancer, Immunology, Metabolism |
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| Description/Background | <p>The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Phosphorylation of this Protein A Affinity purificationlters its catalytic activity and promotes its translocation to the plasma membrane. Alternative splicing results in multiple transcript variants encoding different isoforms.</p> |
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| Protocols | WB |
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| Molecular Weight | 43kDa |
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| Purity | Affinity purification |
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| Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |
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