Anti-CD117 (c-Kit) (Human) pAb (Polyclonal Antibody)
c-Kit, also known as stem cell factor receptor, steel factor receptor or CD117 is classified as a type III receptor tyrosine kinase (RTK) belonging to the platelet-derived growth factor receptor subfamily. Binding of stem cell factor (SCF), known as c-Kit ligand to c-Kit, initiates autophosphorylation of the receptor, subsequently leading to promotes a signal transduction cascade through Ras-Raf-MAP kinase cascade, phosphatidylinositol- 3-kinase, src family kinases, and JAK/STAT pathways. The roles of c-Kit include maturation of hematopoietic and primordial germ cells precursors and melanocytes during embryonic development. In acute myeloid leukemia (AML), c-Kit has been proposed to play a functional role, and becomes target molecule for drug development.
Polyclonal antibody of 6 ml targeting CD117 for ICC, IHC.
| Target | CD117 |
|---|---|
| Product Type | Antibody |
| Application | ICC, IHC |
| Clonality | Polyclonal |
| Conjugate | Unlabeled |
| Isotype | IgG |
| Immunogen | Synthetic peptide C-terminal portion of c-kit gene product carrier protein binding (K963) |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Formulation | In 20 mM HEPES/1% BSA/0.135 M NaCl/0.1% sodium azide |
| Research Area | Epitope Tag, Purification/Separation |
| Storage Temperature | 4°C |
| Protocols | ICC, IHC |
| Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |
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