NKX2-1 Rabbit pAb
| Target | NKX2-1 |
|---|---|
| Product Type | Antibody |
| Application | WB |
| Clonality | Polyclonal |
| Conjugate | unconjugated |
| Isotype | IgG |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 20-110 of human NKX2-1 (NP_003308.1). |
| Host Species | Rabbit |
| Species Reactivity | Human, Rat |
| Formulation | PBS with 0.09% Sodium azide,50% glycerol |
| Research Area | CancerEpigenetics |
| Description/Background | This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TTF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription. |
| Storage Temperature | Store at -20℃ |
| Protocols | WB |
| Molecular Weight | 39kDa |
| Purification | Affinity purification |
| Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |