Integrin alpha V (ITGAV/CD51) Rabbit pAb
| Target | Integrin alpha V (ITGAV/CD51) |
|---|---|
| Product Type | Antibody |
| Application | IHC (P), IP, WB |
| Clonality | Polyclonal |
| Conjugate | unconjugated |
| Isotype | IgG |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 950 to the C-terminus of human Integrin alpha V (ITGAV/CD51) (NP_002201.1). |
| Host Species | Rabbit |
| Species Reactivity | Human, Mouse, Rat |
| Formulation | PBS with 0.09% Sodium azide,50% glycerol |
| Research Area | Cancer |
| Description/Background | The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. |
| Storage Temperature | Store at -20℃ |
| Protocols | IHC (P), IP, WB |
| Molecular Weight | 116kDa |
| Purification | Affinity purification |
| Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |