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WISP2 Rabbit pAb

CNA7456S1
100 µl

THIS ITEM HAS BEEN DISCONTINUED

DATA SHEET

TargetRecombinant fusion protein containing a sequence corresponding to amino acids 164-250 of human WISP2 (NP_003872.1).
Product TypeAntibody
ApplicationIHC (P), WB
ClonalityPolyclonal
Conjugateunconjugated
IsotypeIgG
ImmunogenRecombinant fusion protein containing a sequence corresponding to amino acids 164-250 of human WISP2 (NP_003872.1).
Host SpeciesRabbit
Species ReactivityHuman, Mouse, Rat
FormulationPBS with 0.09% Sodium azide,50% glycerol
Research AreaCancerEpigenetics
Description/BackgroundThis gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse Protein A Affinity purificationt the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.
Storage TemperatureStore at -20℃
ProtocolsIHC (P), WB
Molecular Weight27kDa
PurificationAffinity purification
Regulatory StatementFor Research Use Only. Not for use in diagnostic procedures.
CNA7456S1
100 µl

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