Anti-Integrin αvβ6 ELISA Kit (US only)
This product is only available in the US
5288
ELISA Kit
96 Wells
$2,880.00
Anti-Integrin αvβ6 ELISA Kit is intended to be used for quantitative measurement of anti-integrin αvβ6 antibody in human serum samples.
The Standard material and Reaction buffer contains 0.09% sodium azide as a preservative. If these reagents get into the eyes or mouth, or on the skin, first-aid measures should be taken, such as flushing with water, in addition to seeking medical attention if deemed necessary. Carefully handle the Stop solution and avoid any contact with the eyes, mouth, or skin because this reagent contains sulfuric acid. If contact occurs, immediately flush the affected area with copious amounts of water and seek medical attention if deemed necessary.
| Target | Integrin alpha-V / Beta-6 |
|---|---|
| Product Type | ELISA Kit |
| Application | ELISA |
| Research Area | Cell Biology |
| Description/Background | Integrins are heterodimeric cell surface receptors involved in cell-extracellular matrix and cell-cell adhesion. In addition, integrins convey two-way signaling between cells and their surroundings and participate in the regulation of a variety of cellular processes, including cell proliferation, migration, survival, tissue invasion, and innate immunity. Mammalian cells have 18 distinct integrin α subunits and 8 β subunits, which can combine in various ways to form 24 different receptor heterodimers. Integrin αvβ6 is expressed exclusively by epithelial cells and functions as a receptor for extracellular matrix proteins such as fibronectin. Furthermore, integrin αvβ6 expressed in the intestinal epithelium is involved in suppression of inflammation and prevention of pathogen and parasite infection. Anti-integrin αvβ6 antibodies have been detected in the vast majority of the patients with ulcerative colitis, and its titers have been reported to correlate with disease activity. |
| Storage Temperature | Upon receipt, store all components at 2–8°C. The expiration date of the reagents is indicated on the outer packaging. |
| Protocols | ELISA |
| Sensitivity | 0.4 U/mL |
| Publications | 1. Koivisto L, Bi J, Häkkinen L, Larjava H. Integrin αvβ6: Structure, function and role in health and disease. Int J Biochem Cell Biol. 2018;99:186-96. 2. Kuwada T, Shiokawa M, Kodama Y, Ota S, Kakiuchi N, Nannya Y, et al. Identification of an Anti-Integrin αvβ6 Autoantibody in Patients With Ulcerative Colitis. Gastroenterology. 2021;160(7):2383-94.e21. |
| Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |
This product is only available in the US
5288
ELISA Kit
96 Wells
$2,880.00
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