iTAg Tetramer/APC – Mamu-A*01 SIV gag (CTPYDINQM)

DATA SHEET

Nonhuman primates (NHP) resemble humans in multiple ways including similarities in genomics,  immunogenetics, and age-related changes in immune function. These characteristics are critical to the establishment of a relevant model in which to conduct preclinical studies to optimize the efficacy and safety of  therapeutic approaches. Importantly, NHPs are vital preclinical models for viruses as viral infections are frequently associated with the same pathologies. Hence, NHPs are immune models to study viral vaccine efficacy and antiviral therapeutic safety and efficacy and to understand aspects of viral pathogenesis. Over numerous preclinical studies for human viral diseases, NHPs have demonstrated to be a beneficial benchmark for investigating human viral infections.

MHC Tetramers are used for the detection of antigen-specific T-cell populations. MHC-peptide tetramer complexes recognize antigen specific T-cells at the single cell level, allowing for accurate measurements of the functional immune response in cancer, infectious diseases, and autoimmune diseases.  Due to their increased avidity, MHC tetramers stably bind to cognate TcRs and are evaluated using flow cytometry.